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Bisabolol

Derived from chamomile, it’s known for exceptional anti-inflammatory and wound-healing capabilities

Bisabolol

INGREDIENT PROFILE

synonyms

alpha-Bisabolol Bisabolol 515-69-5 (+)-alpha-Bisabolol 23178-88-3

INCI

Bisabolol

What it Is

A natural monocyclic sesquiterpene alcohol

What it does

strong anti-inflammatory

Targets

excellent antimicrobial Suppress AGE-induced inflammatory reactions, and extracellular matrix degeneration via blocking of NF-kappaB, p38 and JNK signalling

Overview

Derived from chamomile, Bisabolol stands out for its exceptional anti-inflammatory and wound-healing capabilities. It targets core skin irritant molecules including IL1-alpha, IL-6, IL8, and TNF-alpha. Moreover, Bisabolol enhances skin penetration remarkably, making it highly effective in delivering therapeutic benefits deep within the skin. Bisabolol also plays a role in suppressing AGE-induced inflammatory reactions and preventing extracellular matrix degeneration by blocking NF-kappaB, p38, and JNK signaling pathways.

Skin benefits

Anti-inflammatory properties can help reduce redness Wound healing capability can help with eczema and reducing skin surface of wounds

What research has shown

Alpha-bisabolol (α-bisabolol), an unsaturated monocyclic sesquiterpene alcohol, is known as one of the most-used herbal constituents. Its antioxidant properties are primarily linked to reducing reactive oxygen and nitrogen species (ROS/RNS), malondialdehyde (MDA), and glutathione (GSH) depletion, while enhancing myeloperoxidase (MPO) activity, superoxide dismutase (SOD), and catalase (CAT) levels. α-Bisabolol also demonstrates anti-apoptotic capabilities through the upregulation of bcl-2 expression and the downregulation of bax, P53, APAF-1, caspase-3, and caspase-9. Its anti-inflammatory actions are evident in the decreased levels of TNF-α, IL-1β, IL-6, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2), along with inhibited activation of ERK1/2, JNK, NF-κB, and p38 pathways. The compound's antimicrobial benefits stem from its ability to decrease the viability of infected cells, alongside enhancing cognitive functions by lowering levels of bax, cleaved caspases-3 and 9, β-secretase, and cholinesterase activities and increasing bcl-2 levels.

Peer reviewed science

  • Life Sciences (2022)
  • Nutrients (2022)
  • International immunopharmacology (2020)
Vegan
Pregnancy safe
Cruelty free
Fragrance free
Dye free
Silicone free
Refillable
EU approved
Vegan
Pregnancy safe
Cruelty free
Fragrance free
Dye free
Silicone free
Refillable
EU approved